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目的评价萘替芬酮康唑乳膏联合阿达帕林凝胶治疗花斑糠疹的临床疗效及安全性。方法将入选的65例花斑糠疹患者随机分为2组,治疗组予萘替芬酮康唑乳膏和阿达帕林凝胶外,对照组予萘替芬酮康唑乳膏外用,疗程均为2周,分别于治疗结束时及结束后2周时比较两组患者的真菌清除率及临床疗效。结果治疗结束时和治疗结束后2周时,治疗组的有效率为84.85%和96.97%,对照组为62.50%和75.00%,差异均有统计学意义(P均<0.05)。且两组患者中均未见严重不良反应。结论萘替芬酮康唑乳膏联合阿达帕林凝胶治疗花斑糠疹疗效较好,二者联合使用对治疗花斑糠疹有协同治疗作用。
Objective To evaluate the clinical efficacy and safety of naftifine ketoconazole cream combined with adapalene gel in the treatment of pityriasis pityriasis. Methods The selected 65 cases of Pityriasis pityriasis were randomly divided into two groups, the treatment group to nifedipine ketoconazole cream and adapalene gel, the control group to naftifine ketoconazole cream for external use, treatment Were 2 weeks, respectively, at the end of treatment and 2 weeks after the end of the two groups of patients compared fungal clearance and clinical efficacy. Results At the end of treatment and 2 weeks after the end of treatment, the effective rates of the treatment group were 84.85% and 96.97%, while those of the control group were 62.50% and 75.00%, respectively. The differences were statistically significant (all P <0.05). And no serious adverse reactions in both groups of patients. Conclusion Naftifine ketoconazole cream combined with adapalene gel treatment of pityriasis pectoris better effect, the combination of the two for the treatment of pityriasis pityriasis have a synergistic effect.