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几个“长的非编码RNAs”(lncRNAs)已知在前列腺癌中过度表达。Michael Rosenfeld及同事研究了这些“长的非编码RNAs”中的两个的机制功能和生物功能,它们分别是PRNCR1和PCGEM1。二者都被发现依赖于特定的翻译后修饰与雄性激素受体(AR)发生相互作用,增强与AR结合在一起的增强子向目标基因启动子的成环作
Several “long non-coding RNAs” (lncRNAs) are known to be overexpressed in prostate cancer. Michael Rosenfeld and colleagues studied the mechanistic and biological functions of two of these “long non-coding RNAs”, PRNCR1 and PCGEM1, respectively. Both have been found to rely on specific posttranslational modifications to interact with the androgen receptor (AR) and to enhance the looping of enhancers that bind to AR toward the promoter of the target gene