获得性免疫的刺激与反应

• 作 者: 孙澍汉
• 机 构: 河北医学院寄生虫学教研室,
• 出 处: 医学动物防制
• 发表日期: 1985年02期
• 关键词: 宿主免疫 致敏性 啮齿动物 持续时间 虫体 寄生虫学教研室 汉节

本文研究了啮齿动物(jird)感染了线虫 Nemato spiroiaesaudiusdes 之后而对其产生的获得性免疫。一个包括一或二条虫体的最初感染,即具有很高的致敏性。快速感染与获得性免疫有关。在致敏后的第11天,仅见少数虫体在获得了免疫力的动物体内发育成熟,并且,很快被排除,到第16天虫体几乎全部被除体外。缓慢感染在延长最初感染的持续时间上是无助的。这些说明:啮齿类对 N.dubius 感染的异常敏感性将使即便是极少量的奇生虫分泌物也能够起到维持宿主免疫状态的作用。

This article studies the acquired immunity to jirds infected with the nematode Nemato spiroiaeaudiusdes. An initial infection involving one or two parasites, that is, a high sensitization. Rapid infection is associated with acquired immunity. On the 11th day after sensitization, only a few of the parasites were found to mature in the immunized animals, and were quickly excluded. By the 16th day, almost all parasites were ex-vivo. Slow infection is helpless in prolonging the duration of the initial infection. These indicate that the unusual sensitivity of rodents to infection with N..dubius will enable even a very small amount of miracle worm secretions to function to maintain host immune status.