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11例29～39岁有正常月经周期的妇女,每例均在理想体重的20%之内,在受试前至少3个月未用口服避孕药或其他激素。研究连续观察3个周期,每例在第1、3周期从月经第1天起每天口服安慰剂,在第2周期从月经第1天起每天服米非司酮5mg(6例)或2mg(5例),受试者不知服药顺序。在每次月经的第1天和米非司酮治疗的最后一天收集血液标本以测定ACTH和皮质醇,每周三次收集晨尿以测定雌酮、孕二醇、LH和肌酸酐。ACTH、LH、皮质醇用放免法测定,雌酮和孕二醇用酶联免疫吸附试验。统
Eleven patients aged 29-39 years with normal menstrual cycles, each within 20% of ideal body weight, were given no oral contraceptives or other hormones at least 3 months prior to the test. Study continuous observation of three cycles, each case in the first and third cycles from the first day of menstruation daily oral placebo, in the second cycle from the first day of menstruation daily mifepristone 5mg (6 cases) or 2mg ( 5 cases), subjects do not know medication order. Blood samples were collected on day 1 of each menstrual period and on the last day of mifepristone treatment to determine ACTH and cortisol, and morning urine was collected three times per week to determine estrone, gestodeneol, LH, and creatinine. ACTH, LH, Cortisol by radioimmunoassay, estrone and gestodenediol by enzyme-linked immunosorbent assay. System