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目的：探讨ｐ５３、ｐ１６两种抑癌基因蛋白表达在乳腺癌预后及转移中的价值。方法：应用免疫组化法对７６例人乳腺癌石蜡包埋组织进行ｐ５３及ｐ１６蛋白表达研究。结果：ｐ５３蛋白表达阳性组肿瘤的组织学分级、腋窝淋巴结转移率高于ｐ５３蛋白表达阴性组，两组相差显著（Ｐ＜０．０５）和非常显著（Ｐ＜０．０１），而ｐ５３蛋白表达阳性组术后生存期则低于阴性组（Ｐ＜０．０１）；ｐ１６蛋白表达阳性组的腋窝淋巴结转移率、术后生存期则均低于阴性组（分别为Ｐ＜０．０１和Ｐ＜０．０５）。结论：ｐ５３与ｐ１６蛋白表达可以作为判断乳腺癌患者预后的一个重要参考指标
Objective: To investigate the value of p53 and p16 tumor suppressor gene protein expression in the prognosis and metastasis of breast cancer. Methods: Immunohistochemistry was used to study the expression of p53 and p16 proteins in paraffin-embedded tissues of 76 human breast cancer patients. Results: The histological grade and axillary lymph node metastasis rate of tumors with positive p53 protein expression were higher than those with negative p53 protein expression. The difference between the two groups was significant (P<0.05) and very significant (P<0.01). The positive survival rate in the positive group was lower than that in the negative group (P<0.01). The axillary lymph node metastasis rate and the survival time in the positive p16 protein expression group were lower than those in the negative group (P<0.01 and P<0.05). Conclusion: The expression of p53 and p16 protein can be used as an important reference to predict the prognosis of breast cancer patients.