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我们在过去进行“结核菌对异烟肼的耐药性与致病力的关系”的研究中,发现肺结核病患者经异烟肼治疗后,虽全部产生了耐药性,但在临床上却大多数仍有不等程度的进步。经动物次代接种证明,这种矛盾现象是由于结核菌的耐药程度有不均一的情况所致。但在试管中经人工诱导而成的耐药菌株,其耐菸性的增高与致病力的降低是平行的,因此得出药物长期治疗的实验根据。紧接这一工作,我们又做了“异烟肼对敏感与耐异烟肼结核菌感染小白鼠的实验疗效”研究,证明小白鼠经敏感菌株感染者,异烟肼的疗效非常显著,但对耐异烟肼菌感染的小白鼠,则无疗效可见。以上实验所采用的菌株系从痰样中分离出来的,从肺切除标本中研究细菌的生理情况应为更进一步的要求。在这一方面,国外的资料很多。在国
In the past, “Mycobacterium tuberculosis isoniazid resistance and pathogenicity of the relationship” study found that patients with tuberculosis after isoniazid treatment, although all have been drug-resistant, but in clinical Most still have varying degrees of progress. Proved by the second generation of animals vaccination, this contradiction is due to the degree of resistance of M. tuberculosis due to the uneven situation. However, the resistant strains induced by artificial induction in test tubes were parallel to the reduction of pathogenicity, so the experimental basis of long-term drug treatment was obtained. Followed by this work, we have done a “isoniazid sensitive and isoniazid-resistant mice infected with TB experimental study of mice” to prove that mice infected with sensitive strains, isoniazid’s curative effect is very significant, but Infectious isoniazid-resistant mice, no effect can be seen. The strains used in the above experiments were isolated from sputum samples. It is a further requirement to study the physiological conditions of bacteria from lung resection specimens. In this regard, a lot of information abroad. In the country