Cancer and age related colonic crypt deficiencies in cytochrome c oxidase Ⅰ

• 作 者: Carol Bernstein Alexander Faci
• 机 构: DepartmentofCellBiologyandAnatomy,SchulichSchoolofCivilEngineering,DepartmentofCellBiologyandAnatomy
• 出 处: 世界胃肠肿瘤学杂志：英文版（电子版）
• 发表日期: 2010年12期
• 关键词: CYTOCHROME c OXIDASE Aging Colon crypts Colorectal CANCER Focal lesions Cytochro
• 基金项目: Supported by Grants from the National Institutes of Health (5 R01 CA119087),Arizona Biomedical Research Commission Grant #0803,Veterans Affairs Merit Review Grant 0142 administered by the Southern Ari

AIM: To investigate whether defi ciency of expressionof cytochrome c oxidase I (CcOI) in colonic crypts is associated with colon cancer.METHODS: The pattern and level of expression of CcOI in non-neoplastic colonic crypts,and in dysplastic tissues,was ass