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目的 :探讨中药制剂抑瘤宝对恶性肿瘤的作用。方法 :将 Hep瘤细胞接种于昆明种小鼠皮下 ,通过灌胃 ,两组给予抑瘤宝。用免疫组化检测肿瘤组织的 p16、 C- erb B- 2、 p5 3、 Ki- 6 7。结果 :给高剂量抑瘤宝的 A组肿瘤侵犯皮肤发生率为 18.18% ,明显低于低剂量组 (6 6 .6 7% )及对照组 (6 5 % ) (P <0 .0 5 ) ;而 p16阳性表达指数 (12 .72 )明显高于低剂量组 (6 .6 7)及对照组 (7.5 )。各组间 C- erb B- 2及 Ki- 6 7表达率无显著差异。结论 :高剂量抑瘤宝能明显抑制 Hep癌细胞侵润性生长 ;对 Hep癌细胞的增殖有一定抑制作用。
Objective: To investigate the effect of Chinese medicine preparation anti-tumor treasure on malignant tumors. Methods: Hep tumor cells were inoculated subcutaneously in Kunming mice and gavage was given to the two groups. The tumor tissues were examined for p16, C-erb B-2, p53, and Ki-6 by immunohistochemistry. Results: The incidence of aggression of skin in group A with high dose of Yiliubao was 18.18%, which was significantly lower than that of low dose group (66.67%) and control group (65%) (P < 0.05). The positive expression index of p16 (12.72) was significantly higher than that of the low dose group (6.67) and the control group (7.5). There was no significant difference in the expression rates of C-erb B-2 and Ki-67 among the groups. Conclusion : High-dose Xiliubao can significantly inhibit the invasive growth of Hep cells, and inhibit the proliferation of Hep cells.