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切断老年鼠（２４月龄）左侧穹窿海马伞，造成隔海马胆碱能系统损伤模型。用免疫组化方法分析脑室注射ＮＧＦ对基底前脑神经生长因子受体（ＮＧＦ－Ｒ）阳性神经元损伤的影响、实验证明损伤一个月后，损伤对照组损伤例内侧隔核和斜角带核垂直支ＮＧＦ－Ｒ阳性神经元数量分别减少了５９．４％和３７．２４％，残存的神经元发生萎缩及表面受体含量增加。ＮＧＦ治疗组，损伤侧的内侧隔核和斜角带核垂直支的ＮＧＦ－Ｒ阳性神经元数量只减少４．４７％和２．３６％，细胞形态学参数及受体灰度值都类似于正常。提示ＮＧＦ对基底前脑ＮＧＦ－Ｒ阳性神经元损伤后有较好的保护作用。
The left fimbria of the aged mouse (24 months old) was severed, resulting in a cholinergic system injury model of the septum hippocampus. Immunohistochemistry was used to analyze the effect of intracerebroventricular injection of NGF on nerve growth factor receptor (NGF-R) -positive neurons injury in basal forebrain. The experimental results showed that within one month after injury, the septal and diagonal nuclei The number of vertical branch of NGF-R positive neurons decreased by 59.4% and 37.24% respectively, the atrophy of residual neurons and the increase of surface receptor content. In the NGF group, the number of NGF-R positive neurons in the medial septum and the vertical branches of the diagonal nucleus decreased by only 4.47% and 2.36%, respectively, and both morphological parameters and receptor gray values were similar normal. These results suggest that NGF may have a good protective effect on NGF-R-positive neurons in the basal forebrain.