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目的探讨奥沙利铂联合亚叶酸钙、5-氟尿嘧啶治疗晚期结直肠癌的临床效果及不良反应。方法选取2011年5月至2013年5月收治的晚期结直肠癌患者46例,均行奥沙利铂+亚叶酸钙+5-氟尿嘧啶治疗,并观察治疗效果。结果治疗后完全缓解6例,部分缓解25例,稳定15例,进展0例,总有效率67.4%。结肠癌与直肠癌患者有效率分别为67.8%、66.7%,二者差异无统计学意义(P>0.05)。患者不良反应主要有呕吐(50.0%)、恶心(47.8%)、血小板减少(54.3%)、神经感觉异常(73.9%)等。均未出现心脏、肝肾功能损害,无化疗相关死亡。结论奥沙利铂联合亚叶酸钙及5-氟尿嘧啶治疗晚期结直肠癌患者效果明显,不良反应发生率低,安全性高,可作为临床治疗晚期结直肠癌的一种有效方法。
Objective To investigate the clinical effects and adverse reactions of oxaliplatin combined with leucovorin and 5-fluorouracil in the treatment of advanced colorectal cancer. Methods Forty-six patients with advanced colorectal cancer admitted to our hospital from May 2011 to May 2013 were treated with oxaliplatin + leucovorin + 5-fluorouracil and the therapeutic effects were observed. Results After treatment, complete remission in 6 cases, partial remission in 25 cases, stable in 15 cases, 0 cases of progress, the total effective rate was 67.4%. The effective rates of colon cancer and rectal cancer were 67.8% and 66.7% respectively, with no significant difference between the two groups (P> 0.05). The main adverse reactions were vomiting (50.0%), nausea (47.8%), thrombocytopenia (54.3%), neurosensory abnormalities (73.9%) and so on. No heart, liver and kidney dysfunction, no chemotherapy-related deaths. Conclusion Oxaliplatin in combination with leucovorin and 5-fluorouracil is effective in patients with advanced colorectal cancer. The incidence of adverse reactions is low and the safety is high. It can be used as an effective method for clinical treatment of advanced colorectal cancer.