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目的：探讨系统性红斑狼疮（SLE）对重度妊高征（PIH）发病影响及对母儿危害。方法：80例SLE妊娠的临床资料前瞻性研究。结果：活动期SLE肾炎孕妇合并重度PIH的发生率10／22例（45％）。稳定期SLE肾炎1／12例（83％），其它皮肤型SLE2／46例（4．3％）。文献报告[1]活动期SLE肾炎与重度PIH很难鉴别且母死亡率可高达50％～80％，胎儿死亡率12．9％～45．5％[1，5]。结论：两者诊断正确时，分别给予增加激素控制活动及硫酸镁控制病情，适时干预性早产，羊膜腔内注射地塞米松，可使孕妇转危为安及提高早产儿成活率。本文孕妇80例及新生儿81例（双胎1例）均存活。
Objective: To investigate the impact of systemic lupus erythematosus (SLE) on the incidence of severe pregnancy-induced hypertension (PIH) and its harm to mothers and children. Methods: The clinical data of 80 cases of SLE pregnancy were prospectively studied. Results: The incidence of active PIH in active SLE nephritis pregnant women was 10/22 (45%). Stable SLE nephritis in 1/12 cases (83%), other skin type SLE2 / 46 cases (4.3%). Literature reports [1] active SLE nephritis and severe PIH is difficult to identify and the mother’s death rate can be as high as 50% to 80%, fetal mortality rate of 12.9% to 45.5% [1,5]. Conclusion: When the two are correctly diagnosed, they are given hormonal control activities and magnesium sulfate to control the disease respectively. Interventional premature labor and intra-amniotic injection of dexamethasone can make the pregnant woman turn the corner and improve the survival rate of premature infants. In this paper, 80 pregnant women and 81 newborns (twin cases) survived.