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目的:探讨硝普钠结合胺碘酮治疗老年高血压伴心衰的临床疗效。方法:将46例慢性充血性心力衰竭患者随机分观察组和对照组,每组23例,两组在治疗过程中原抗心衰药物不变,观察组在原治疗基础上口服硝普钠结合胺碘酮。对照组在原治疗基础上口服卡托普利。结果:治疗结束后,两组心功能均较前有所改善,治疗组总有效率87.0%,对照组总有效率78.3%,两组间比较差异无统计学意义(P>0.05)。观察组心率较治疗前减慢,差异有显著性(P<0.01),心胸比率缩小(P<0.05),LVEF较治疗前升高,比较有统计学意义(P<0.05),对照组心率、心胸比、LVEF等指标改善较治疗前比较差异亦有统计学意义(P<0.05),两组治疗后各项指标差异不明显(P>0.05)。结论:硝普钠结合胺碘酮片治疗慢性充血性心衰可以明显改善心功能,改善心脏收缩和舒张功能,提高生活质量,不良反应少。
Objective: To investigate the clinical efficacy of sodium nitroprusside combined with amiodarone in the treatment of elderly patients with hypertension and heart failure. Methods: 46 cases of chronic congestive heart failure patients were randomly divided into observation group and control group, 23 cases in each group, the two groups in the course of the treatment of anti-heart failure drug unchanged, the observation group on the basis of the original treatment of oral sodium nitroprusside with amiodarone ketone. The control group received captopril on the basis of the original treatment. Results: After the treatment, both groups had better heart function than before. The total effective rate was 87.0% in the treatment group and 78.3% in the control group. There was no significant difference between the two groups (P> 0.05). The heart rate of the observation group was slower than that before treatment, the difference was significant (P <0.01), the ratio of cardiothoracic and thorax decreased (P <0.05), LVEF increased compared with that before treatment (P <0.05) Cardiothoracic ratio, LVEF and other indicators of improvement than before treatment were also statistically significant differences (P <0.05), the two groups after treatment, the indicators were not significantly different (P> 0.05). Conclusion: Sodium nitroprusside combined with amiodarone tablets in the treatment of chronic congestive heart failure can significantly improve cardiac function, improve cardiac systolic and diastolic function, improve quality of life, fewer adverse reactions.