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目的研究并分析培哚普利、美托洛尔联合治疗慢性心力衰竭的效果。方法 68例慢性心力衰竭患者作为研究对象,按照随机数字表法将其分为实验组和对照组,每组34例。给予对照组常规药物进行治疗,给予实验组培哚普利、美托洛尔进行联合治疗,观察并对比两组患者的治疗效果。结果治疗后,实验组的收缩压为(120.42±11.57)mm Hg(1 mm Hg=0.133 k Pa),舒张压为(70.25±13.41)mm Hg,心率为(71.18±8.23)次/min,左室射血分数(LVEF)为(48.93±8.29)%;对照组的收缩压为(133.52±10.20)mm Hg,舒张压为(81.35±12.47)mm Hg,心率为(93.67±8.77)次/min,LVEF为(35.84±8.37)%。实验组均优于对照组,差异均具有统计学意义(P<0.05)。实验组总有效率为94.12%,高于对照组的70.59%,差异具有统计学意义(P<0.05)。实验组不良反应发生率5.88%低于对照组23.53%,差异具有统计学意义(P<0.05)。结论采用培哚普利与美托洛尔联合的方法对慢性心力衰竭患者进行治疗,可以得到良好的治疗效果,临床应用价值高。
Objective To study and analyze the effect of perindopril combined with metoprolol in the treatment of chronic heart failure. Methods Sixty-eight patients with chronic heart failure were divided into experimental group and control group according to the random number table method, with 34 cases in each group. Give the control group conventional drugs for treatment, given experimental group perindopril, metoprolol combined treatment, observation and comparison of two groups of patients with treatment. Results After treatment, the systolic blood pressure was (120.42 ± 11.57) mm Hg (1 mm Hg = 0.133 kPa), the diastolic blood pressure was (70.25 ± 13.41) mm Hg and the heart rate was (71.18 ± 8.23) The ejection fraction (LVEF) was (48.93 ± 8.29)% in the control group, the systolic pressure was (133.52 ± 10.20) mm Hg, the diastolic pressure was (81.35 ± 12.47) mm Hg, the heart rate was (93.67 ± 8.77) , LVEF was (35.84 ± 8.37)%. The experimental group were better than the control group, the differences were statistically significant (P <0.05). The total effective rate of the experimental group was 94.12%, which was higher than that of the control group (70.59%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the experimental group was 5.88% lower than that in the control group (23.53%), the difference was statistically significant (P <0.05). Conclusion The combination of perindopril and metoprolol in the treatment of patients with chronic heart failure, can be a good therapeutic effect, clinical application of high value.