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4例有哮喘症状的患者,男、女各2例,年龄54～65岁,口服复方妥英麻黄茶碱片4～9片/d,每片含苯妥英钠50mg,每日总剂量为200～450mg,服药时间1～4年。服药期间患者逐渐出现头晕、眼球震颤、步态不稳等症状及小脑性共济失调的体征。检测苯妥英血药浓度34.15～94.12μg/mL,为治疗血药浓度的1.7～4.7倍,诊断为苯妥英钠中毒。停用复方妥英麻黄茶碱片,4～7d后患者中毒症状消失。2例患者复查血药浓度,分别降至1.03、1.14μg/mL。
4 patients with asthma symptoms, 2 males and 2 females, aged 54 to 65 years old, orally taking the compound toepine theophylline tablets 4 to 9 tablets / d, each containing phenytoin sodium 50mg, the total daily dose of 200 ~ 450mg, taking 1 to 4 years. Patients during medication gradually dizziness, nystagmus, gait instability and other symptoms and signs of cerebellar ataxia. Detection of phenytoin plasma concentration 34.15 ~ 94.12μg / mL, for the treatment of plasma concentrations of 1.7 to 4.7 times the diagnosis of phenytoin sodium poisoning. To disable the compound to the United Kingdom Ephedrine theophylline tablets, 4 to 7 days after the patient’s symptoms disappear. The plasma concentrations of 2 patients were examined and decreased to 1.03 and 1.14 μg / mL respectively.