论文部分内容阅读
16,17α-环氧-5α-和5β-孕甾-3β-醇-20-酮(1,2)用诺卡氏菌脱氢分别得到4,5,6, 7和8,5,6,7四个化合物,其中16,17α-环氧-⊿~4-孕甾烯-3,20-双酮(5)是主要产物.1和2分别用节杆菌脱氢时则均得到两个20α-羟基的不饱和化合物15和16,其中⊿~1,4-双酮16是主要产物.16,17α-环氧-16β-甲基-5α-⊿~9(11)-孕甾烯-3β-醇-20-酮(3)用诺卡氏菌脱氢可得到12,13,14三个化合物,其中16,17α-环氧-16β-甲基_-⊿~4,9(11)-孕甾二烯-3,20-双酮(13)是主要产物.综上所述,5α和5β甾族化合物用诺卡氏菌脱氢主要脱去C_4,5两个氢原子形成⊿~4-烯-3-酮化合物,而采用节杆菌可使C_l,2和C_4,5位同时脱氢形成⊿~1,4-双烯-3-酮化合物.
16,17α-epoxy-5α- and 5β-pregna-3β-ol-20-one (1,2) were dehydrogenated with Nocardia to give 4,5,6,7 and 8,5,6, 7, four compounds, among which 16,17α-epoxy-4-pregnen-3,20-dione (5) were the main products, while 1 and 2 were respectively dehydrated with Arthrobacter, -hydroxyl unsaturated compounds 15 and 16, wherein the acenaphthylene-1,4-dione 16 is the major product.16,17α-Epoxy-16β-methyl-5α-⊿ ~ 9 (11) -pregnadiene-3β (3) dehydration with Nocardia 12,13,14 can be obtained three compounds, including 16,17α-epoxy-16β-methyl _-⊿ ~ 4,9 (11) - Pregnen-3,20-dione (13) is the main product.In summary, the 5α and 5β steroids with Nocardia dehydrogenation mainly C_4,5 two hydrogen atoms off ⊿ ~ 4 -en-3-one compound, while using Arthrobacter can C_l, 2 and C_ 4,5-position dehydrogenation to form ~ ~ 1,4-dien-3-one compound.