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为探讨癌胚抗原（ＣＥＡ）对判断大肠息肉癌变危险性的价值，应用ＣＥＡ、ＭｃＡｂ借助免疫胶体金银染色法（ＩＧＳＳ）对大肠正常粘膜、息肉及癌组织中ＣＥＡ进行检测，结果显示：多数大肠正常粘膜、炎性息肉及幼年性息肉ＣＥＡ呈现阴性，仅少数ＣＥＡ呈弱阳性，染色见于腺体细胞腔面，与上述各组比较，大肠增生性息肉和腺瘤组织ＣＥＡ阳性率和染色程度均增高，随着腺瘤组织异型程度加重，其免疫组化改变及ＣＥＡ分布更类似于大肠癌，结果提示ＣＥＡ可作为监测大肠息肉癌变的标志物。ＩＧＳＳ染色法操作简便、敏感性高，值得推广应用
To investigate the value of carcinoembryonic antigen (CEA) in judging the risk of colorectal polyposis, CEA and McAb were used to detect CEA in normal mucosa, polyps, and cancer tissues by immunogold gold staining (IGSS). The results showed that: The CEA of normal colon mucosa, inflammatory polyps, and juvenile polyps were negative, only a few CEA were weakly positive, and staining was found on the luminal surface of glands. Compared with the above groups, CEA positive rate and staining degree of colon hyperplasia polyps and adenomas All increased, with aggravated adenoma tissue, the immunohistochemical changes and CEA distribution more similar to colorectal cancer, the results suggest that CEA can be used as a marker for monitoring colorectal polyposis. The IGSS staining method is easy to operate and has high sensitivity and is worthy of popularization and application.