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目的探讨南京及周边地区儿童手足口病发病特征,为早期识别重症手足口病提供依据。方法 2009年3～6月和2010年3～6月住院的手足口病802例,重症型病例421例,普通型病例381例。结果患儿血白细胞、血糖的增高及发热天数与手足口病病情分型有相关性。病原学检测,发现手足口病感染主要以EV71病毒为主,2010年尤为突出。与2009年比较,在流行特征上,2010年手足口病重症患儿有低龄化趋势;在重症型病例中,2010年病毒性脑(膜)炎、神经源性肺水肿发病率上升。结论临床上对手足口病EV71病毒感染、低龄儿尤其年龄小于1岁、高热持续不退、热程长的患儿,应重点关注。
Objective To explore the characteristics of hand-foot-mouth disease in children in Nanjing and its surrounding areas, and to provide evidence for the early identification of severe hand-foot-mouth disease. Methods From March to June in 2009 and March to June in 2010, 802 cases of hand-foot-mouth disease, 421 cases of severe cases and 381 cases of common type were hospitalized. Results Children with leukocytosis, elevated blood glucose and fever days and hand, foot and mouth disease disease classification is related. Etiological detection, found that hand, foot and mouth disease mainly EV71 virus infection, especially in 2010. Compared with 2009, the epidemic characteristics of 2010 HFMD children have the trend of younger age; in severe cases, the incidence of viral brain (membranous) inflammation and neurogenic pulmonary edema in 2010 increased. Conclusion EV71 virus infection in hand, foot and mouth disease, especially in young children younger than 1 year old, persistent high fever, fever long children, should focus on.