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1 糖尿病的肝脏改变糖尿病常合并多种脏器的慢性病变,可累及心、肾、脑、视网膜、神经等.有关糖尿病引起肝脏病变的报告不多.且其病变程度较心、肾、眼等处为轻.诸星等报告24例糖尿病肝活检及12例糖尿病尸检结果.24例活检中17例(70%)伴脂肪变性(2例高度,1例中度,14例轻度),10例(29%)有核空泡化,22%可见微血管病变.12例尸检中,脂肪变性67%,核空泡化75%、微血管病变67%.糖尿病的肝脏病变可归纳为以下几方面:(1)肝细胞脂肪变性最为常见.脂肪变性与糖尿病病程和病情控制状况无明显关系、而与肥胖程度有密切关系.(2)核空泡化:此为糖尿病性肝损害较富特征性的改变之一.其发生机理与核内糖元蓄积过多有关.核内空泡多发生在门脉区周围(即小叶边缘部)的肝细胞.(3)部分糖尿病的肝组织内可见脂肪肉芽肿,系因脂肪滴从肝细胞中漏出至间质中所
1 diabetic liver changes often associated with diabetes and chronic diseases of multiple organs, can affect the heart, kidney, brain, retina, nerves, etc. The report of diabetic liver disease caused by small, and the lesion of the heart, kidney, eye and other 24 cases of biopsy in 17 cases (70%) with steatosis (2 cases of height, 1 case of moderate, 14 cases of mild), 10 (29%) had nuclear vacuolization and 22% visible microvascular disease.Among the 12 autopsy samples, 67% of steatosis, 75% of nucleolus and 67% of microvascular disease.Diabetic liver lesions can be summarized as follows: (1) Steatosis of hepatocytes is the most common, and there is no significant relationship between steatosis and the course of diabetes and the control of disease, but closely related to the degree of obesity (2) Nuclear vacuolization: This is a characteristic feature of diabetic liver damage One of the changes in the mechanism of its occurrence is related to the excessive accumulation of glycogen in the nucleus.Novo of nucleus occurs mostly in the hepatocytes around the portal area (ie, the edge of the leaflet). (3) Fatty granulation Swollen, due to fat droplets from the liver cells to the interstitial leakage