Primary hepatic benign schwannoma

• 作 者: Michihiro Hayashi Atsushi Takeshita Kazuhiro Yamamoto Nobuhiko Tanigawa
• 机 构: Department of General and Gastroenterological Surgery,Department of Pathology, Department of Radiolo
• 出 处: World Journal of Gastrointestinal Surgery
• 发表日期: 2012年03期
• 关键词: neoplasm intestine predominantly Schwann sheath recurrence extremely metastatic

Schwannoma is predominantly a benign neoplasm of the Schwann cells in the neural sheath of the peripheral nerves.Occurrence of schwannoma in parenchymatous organs,such as liver,is extremely rare.A 64-year-old man without neurofibromatosis was observed to have a space-occupying lesion of 23mm diameter in the liver during follow-up examination for a previously resected gastrointestinal stromal tumor(GIST)in the small intestine.He underwent lateral segmentectomy of the liver under a provisional diagnosis of hepatic metastatic recurrence of the GIST.Histological examination confirmed the diagnosis of a benign schwannoma,confirmed by characteristic pathological findings and positive immunoreactions with the neurogenic marker S-100 protein,but negative for c-kit,or CD34.The tumor was the smallest among the reported cases.When the primary hepatic schwannoma is small in size,preopera- tive clinical diagnosis is difficult.Therefore,this disease should be listed as differential diagnosis for liver tumor with clinically benign characteristics.

Schwannoma is predominantly a benign neoplasm of the Schwann cells in the neural sheath of the peripheral nerves. Occurrence of schwannoma in parenchymatous organs, such as liver, is extremely rare. A 64-year-old man without neurofibromatosis was observed to have a space- occupying lesion of 23mm diameter in the liver during follow-up examination for a previously resected gastrointestinal stromal tumor (GIST) in the small intestine. He underwent lateral segmentectomy of the liver under a provisional diagnosis of hepatic metastatic recurrence of the GIST. the diagnosis of a benign schwannoma, confirmed by characteristic pathological findings and positive immunoreactions with the neurogenic marker S-100 protein, but negative for c-kit, or CD34. tumor was the smallest among the reported cases. WHERE the primary hepatic schwannoma is small in size, preopera- tive clinical diagnosis is difficult.Therefore, this disease should be listed as differential diagnosis for liv er tumor with clinically benign characteristics.