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目的观察比较利尿药物与自身腹水超滤浓缩回输治疗肝硬化腹水患者的临床效果。方法选取医院收治的肝硬化腹水患者48例,依据治疗方法将入选患者分为药物组27例和超滤浓缩组21例。药物组给予常规药物治疗,超滤浓缩组给予自体腹水超滤浓缩回输治疗。观察2组患者治疗后的血钠、尿钠及肝功能情况,评估并统计2组腹水消退情况。结果超滤浓缩组总消退率为80.95%,明显高于药物组的55.56%(P<0.01)。治疗后,超滤浓缩组患者血钠值、尿钠水平均高于药物组(P<0.05);超滤浓缩组ALT、AST、TBi L数值均低于药物组,ALB数值高于药物组(P<0.05)。结论自身腹水超滤浓缩回输治疗肝硬化腹水疗效令人满意,并可显著改善患者的肝功能与血钠、尿钠水平,值得临床治疗中借鉴。
Objective To compare the clinical efficacy of diuretic drugs with ultrafiltration of ascites in patients with cirrhosis and ascites. Methods Forty-eight patients with cirrhosis and ascites admitted to the hospital were enrolled. According to the treatment methods, the patients were divided into two groups: drug group (27 cases) and ultrafiltration group (21 cases). The drug group was given conventional drug treatment, ultrafiltration concentration group given autologous ascites ultrafiltration concentrated back infusion therapy. Two groups of patients were observed after treatment of sodium, urinary sodium and liver function, assessment and statistics 2 groups of ascites regression. Results The total remission rate in the ultrafiltration group was 80.95%, significantly higher than that in the drug group (55.56%, P <0.01). After treatment, the levels of serum sodium and urine sodium in the ultrafiltration group were higher than those in the drug group (P <0.05). The values of ALT, AST and TBi L in the ultrafiltration group were lower than those in the drug group P <0.05). Conclusions The treatment of ascites due to ultrafiltration and aspiration of ascites is satisfactory, and can significantly improve the liver function, serum sodium and natriuretic peptide level of patients, which is worthy of reference in clinical treatment.