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目的探讨不同剂型美托洛尔片对中青年1级原发性高血压患者晨峰血压控制情况、血压波动情况和对自主神经的影响。方法将中青年1级原发性高血压患者245例随机分为琥珀酸美托洛尔片(A组)、酒石酸美托洛尔片(B组)两组,分别给予琥珀酸美托洛尔片逐渐加量至95 mg,1次/d(A组)和酒石酸美托洛尔片逐渐加量至50 mg,2次/d(B组)。观察服药4周后两组患者血压达标率、晨峰血压、血压变异性和心率变异性的变化。结果A组与B组血压达标率没有差异(51.6%比48.8%,P>0.05);A组的晨峰血压、血压变异系数、心率变异性较B组明显改善(P<0.05)。结论琥珀酸美托洛尔片较酒石酸美托洛尔片能更好地降低晨峰血压,24 h降压更平稳,对自主神经紊乱的改善更明显。
Objective To investigate the effect of different dosage forms of metoprolol on morning peak pressure control, blood pressure fluctuation and autonomic nervous system in primary and middle-aged patients with primary essential hypertension. Methods A total of 245 middle-aged and young primary essential hypertension patients were randomly divided into two groups: metoprolol succinate tablets (group A) and metoprolol tartrate tablets (group B), metoprolol succinate The tablets were gradually added to 95 mg once a day (group A) and metoprolol tartrate tablets gradually to 50 mg twice a day (group B). Observe the changes of blood pressure compliance rate, morning blood pressure, blood pressure variability and heart rate variability in the two groups after 4 weeks. Results There was no difference in blood pressure compliance between group A and group B (51.6% vs. 48.8%, P> 0.05). The peak morning blood pressure, blood pressure variability and heart rate variability in group A were significantly improved compared with those in group B (P <0.05). Conclusion Metoprolol succinate tablets can lower the morning peak blood pressure better than metoprolol tartrate tablets, and the blood pressure is more stable at 24 h, and the improvement of autonomic nervous disorder is more obvious.