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目的:设计并合成了一系列六氢苯并［a］喹嗪-4-酮类化合物，对其钙拮抗活性作初步研究；方法:用45 Ca跨膜内流动测定方法研究了目标物对大鼠主动脉电压依赖性钙离子通道（PDC）Ca2+内流的影响；结果:四个化合物对PDC均有显著阻滞作用；结论:初步药理实验显示，四个化合物具有一定的钙拮抗活性。“,”A series of derivatives of hexahydrobenzo［a］quinolizin-4-one have been designed and synthesized. Four of them have been determined on their inhabitive effect on potential-dependent Ca2+channels(PDC).METHODS: The four compounds have been studied on Ca2+ antagonistic effect in rat aorta by using 45 Ca transmembrane influx technique.RESULTS:The four compounds appeared strongly inhabitive effect on PDC.CONCLUSION:Preliminary results showed that all of the four compounds possessed Ca2+ antagonizing activity.