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目的:观察青海高原地区幽门螺杆菌(Hp)相关性胃癌前病变患者血清Th1/Th2细胞因子(IL-1β、IL-2、IL-4、IL-6、IL-8、TNF)水平变化,以探讨其在发病中的可能免疫致病机制。方法:应用放免法(RIA)测定25例慢性萎缩性胃炎(CAG)、17例肠化生(IM)、15例异型增生(Dys)患者血清IL-1β、IL-2、IL-4、IL-6、IL-8、TNF的含量。比较Hp感染与非感染胃癌前病变患者之间;Hp感染CAG炎症活动与非活动患者之间;Hp感染CAG、IM、Dys患者之间血清6种细胞因子含量的差别。结果:Hp感染与非感染胃癌前病变患者之间6种细胞因子含量均无显著性差别(P>0.05);Hp感染CAG炎症活动者血清IL-4含量显著低于非活动者(P<0.05);IM和Dys者均非常显著低于CAG(P<0.01),IL-2在Dys组显著高于CAG(P<0.05)。结论:本地区Hp相关性胃癌前病变中存在血清Th1/Th2失衡,表现为随着胃癌前病变的逐级加重,T淋巴细胞高表达IL-2伴随IL-4低表达现象。
Objective: To observe the changes of serum levels of Th1 / Th2 cytokines (IL-1β, IL-2, IL-4, IL-6, IL-8 and TNF) in patients with Helicobacter pylori associated gastric precancerous lesions in the Qinghai Plateau, To explore its possible pathogenesis in the pathogenesis of immunity. Methods: Serum levels of IL-1β, IL-2, IL-4 and IL-8 in 25 patients with chronic atrophic gastritis (CAG), 17 patients with intestinal metaplasia (IM) and 15 patients with dysplasia (Dys) were determined by radioimmunoassay (RIA) -6, IL-8, TNF levels. The difference between the serum levels of 6 cytokines in Hp-infected CAG, IM, Dys patients was compared between Hp-infected and non-infected gastric precancerous lesions; between Hp-infected CAG inflammatory patients and inactive patients; Results: There was no significant difference in the levels of 6 cytokines between Hp infected and non-infected gastric precancerous lesions (P> 0.05). The serum level of IL-4 in Hp-infected CAG inflammatory patients was significantly lower than that in inactive patients (P <0.05) ). The levels of IL-2 and IL-2 in Dys group were significantly lower than those in CAG group (P <0.05). Conclusion: The imbalance of serum Th1 / Th2 exists in Hp-related gastric precancerous lesions in this region. The expression of IL-2 with high expression of T lymphocytes is associated with the low expression of IL-4 with the gradual increase of gastric precancerous lesions.