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氟是人体必需微量元素之一,是一种已知可影响骨形成的非激素因子,适量氟对人体具有重要生理功能,但长期摄入过量氟可引起以氟斑牙和氟骨症为主的慢性全身性疾病。成骨细胞活跃和骨转换加速是氟骨症特征性病变。通过转录因子调节基因表达是控制细胞功能的重要机制之一,随着基因技术不断发展,在骨骼发育过程中关键转录因子也逐渐被发现,其中有些发挥着决定性作用。本文通过对Dlx5与骨代谢及氟骨症关系研究进展做一综述,为氟骨症防治提供参考依据。
Fluoride is one of the essential trace elements of the human body and is a non-hormonal factor known to affect bone formation. The appropriate amount of fluoride has important physiological functions on the human body. However, excessive intake of fluoride over a long period of time can cause dental fluorosis and skeletal fluorosis Chronic systemic disease. Osteoblast activation and accelerated bone turnover are characteristic features of skeletal fluorosis. Regulation of gene expression by transcription factors is one of the important mechanisms that control cell function. With the continuous development of gene technology, key transcription factors in bone development are gradually found, some of which play a decisive role. This article reviews the research progress of the relationship between Dlx5 and bone metabolism and skeletal fluorosis, and provides a reference for the prevention and treatment of skeletal fluorosis.