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小鼠自腹腔接种2000个细粒棘球蚴原头节后1～2个月,其细胞免疫水平明显升高,3～12个月后,则持续下降。在感染后1～3个月,其血清特异性抗体呈阳性反应,且抗体滴度随感染时间的延长而增高。组织学观察证明,原头节在发育成囊初期,其周围的宿主细胞反应较重,且有大量原头节死亡;感染后期,宿主细胞反应逐渐减轻或消失,对虫囊则无明显影响。
Mice were inoculated intraperitoneally with 2000 Echinococcus granulosus 1 ~ 2 months after the original cell, the cellular immunity was significantly increased, 3 to 12 months, then continued to decline. In 1-3 months after infection, the serum-specific antibody was positive, and antibody titer increased with the extension of infection time. Histological observation showed that the protoscoleces developed in the early stage of cyst formation, and the host cells around the protoscoid had a heavy reaction and a large number of protoscoleces died. In the late stage of infection, the host cell response gradually reduced or disappeared, and had no significant effect on the larvae.