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目的 :探讨尼尔雌醇 (NYL)皮埋剂对卵巢切除 (OVX)大鼠骨强度的影响。方法 :4 6只 6月龄SD大鼠随机分为假手术 (Sham)组、卵巢切除 (OVX)组、卵巢切除加左旋炔诺孕酮皮埋剂 (LNG)组、卵巢切除加LNG皮埋剂和NYL皮埋剂组。实验 4个月后处死大鼠 ,取第 3腰椎 (L3 )和右股骨 ,分别进行腰椎压缩和股骨三点弯曲力学试验。结果 :与Sham组比较 ,OVX组和LNG皮埋剂组大鼠腰椎的抗压强度和最大压缩力下降 (P <0 .0 5～ 0 .0 1) ,而股骨力学指标的差异无显著性 ;LNG +NYL皮埋剂组和NYL皮埋剂组腰椎各力学指标与Sham组接近 ,差异无显著性 ,而股骨的截面惯性矩都降低 (P <0 .0 5 ) ,弹性模量升高 (P <0 .0 5 ) ;NYL皮埋剂组股骨的最大应力升高 (P <0 .0 1)。与OVX组比较 ,LNG +NYL皮埋剂组和NYL皮埋剂组腰椎的最大压缩力和股骨的弹性模量升高 (P <0 .0 5～ 0 .0 1) ,NYL皮埋剂组股骨的最大应力升高 (P <0 .0 5 )。结论 :NYL皮埋剂可改善OVX大鼠腰椎和股骨的力学性能 ,提高骨强度。单纯用LNG皮埋剂不能阻止OVX大鼠腰椎骨强度的下降。
Objective: To investigate the effect of nylestriol (NYL) embedding agent on the bone strength of ovariectomized (OVX) rats. Methods: Six 6-month-old SD rats were randomly divided into Sham group, ovariectomized group (OVX), ovariectomized group (LNG) and LNG group Agent and NYL skin burying agent group. Four months after the experiment, the rats were sacrificed, and the third lumbar vertebra (L3) and the right femur were taken for lumbar compression and femoral three-point bending test. RESULTS: Compared with Sham group, the compressive strength and maximum compressive strength of lumbar vertebrae of rats in OVX group and LNG group were significantly decreased (P <0.05-0.01), but there was no significant difference in femoral mechanical parameters The mechanical indexes of lumbar vertebrae in LNG + NYL skin burying group and NYL skin burying agent group were similar to those in Sham group, while there was no significant difference between them (P <0.05), and the elastic modulus was increased (P <0.05). The maximum stress of the femur in the NYL embedded group increased (P <0.01). Compared with OVX group, the maximum compression force and femoral elastic modulus of lumbar vertebrae in LNG + NYL and NYL group were significantly increased (P <0.05-0.01) The maximum femoral stress increased (P <0.05). CONCLUSION: NYL burial agent can improve the mechanical properties of lumbar spine and femur of OVX rats and increase the bone strength. Simply using LNG skin burial agent can not prevent the decline of lumbar vertebrae bone strength in OVX rats.