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商陆多糖Ⅰ(PEP Ⅰ)10,20mg·kg~1 ip能显著抑制S180生长,最大抑瘤率可达51.7％,Cy 10mg·kg~1 ip.抑瘤率为55.1％,两者合用抑瘤率为68.6％,PEP-Ⅰ治疗能显著促进脾脏增生,但不影响体重,PEP-Ⅰ治疗后,小鼠的T淋巴细胞转化及白介素2(IL-2)产生能力显著高于对照组,计数外周白细胞,骨髓有核细胞并用[~3H]TdR参入法观察rmGM-CSF刺激骨髓细胞增殖.结果表明PEP-Ⅰ与Cy合用治疗至d 11的外周白细胞数,骨髓有核细胞数和骨髓细胞的增殖能力显著高于单用Cy组,以上实验结果说明EPP-Ⅰ可能通过增强T淋巴细胞功能来抑制移植性肿瘤生长,并具有保护造血功能的作用。
PEP Ⅰ 10,20mg · kg ~ 1 ip can significantly inhibit the growth of S180, the maximum inhibitory rate of 51.7%, Cy 10mg · kg ~ 1 ip. The inhibition rate was 55.1%, the two combined The tumor rate was 68.6%. PEP-Ⅰ treatment could significantly promote spleen proliferation but did not affect body weight. After PEP-Ⅰ treatment, T lymphocyte transformation and interleukin 2 (IL-2) production ability of mice was significantly higher than that of the control group, Peripheral leucocytes and bone marrow nucleated cells were counted and the proliferation of bone marrow cells stimulated by rmGM-CSF was observed by [~ 3H] TdR incorporation method.The results showed that the number of peripheral white blood cells, the number of bone marrow nucleated cells and myeloid cells The proliferative capacity of EPP-I was significantly higher than that of Cy alone group. The above results indicate that EPP-I may inhibit the growth of transplanted tumors by enhancing the function of T lymphocytes and have the function of protecting hematopoietic function.