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目的 :评价复方聚维酮碘片 (CPI)的抗炎作用 ,分析其主要成分对抗炎效应的影响。方法 采用巴豆油引起的家兔声带炎症模型和二甲苯引起的小鼠耳炎症模型 ,观察CPI、聚维酮碘 (PI)和双氯芬酸钠 (DS)局部涂抹给药的抗炎作用。结果 CPI和DS局部涂抹给药 ,可明显抑制家兔声带肿胀和炎性渗出 ,减轻小鼠耳肿胀度 ,对两种炎症模型抑制作用均呈剂量相关性。PI局部涂抹给药对家兔声带炎症反应无明显抑制作用。结论 CPI局部用药对家兔声带和小鼠耳炎症反应具有明显抗炎作用。CPI的抗炎作用主要由DS产生
OBJECTIVE: To evaluate the anti-inflammatory effect of compound povidone-iodine tablets (CPI) and analyze the effects of its main components on anti-inflammatory effects. Methods Rabbit model of vocal cord inflammation caused by croton oil and model of otitis caused by xylene were used to observe the anti-inflammatory effects of topical application of CPI, povidone-iodine (PI) and diclofenac sodium (DS). Results Topical application of CPI and DS could significantly inhibit vocal cord swelling and inflammatory exudation in rabbits and relieve ear swelling in mice. The inhibitory effects of CPI and DS were dose-dependent. Topical application of PI did not significantly inhibit the vocal cord inflammation in rabbits. Conclusion The topical CPI has obvious anti-inflammatory effect on the vocal cord of rabbits and the inflammation of ear in mice. The anti-inflammatory effect of CPI is mainly generated by DS