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目的研究食管癌组织中巨噬细胞移动抑制因子(macrophage migration inhibitory factor,MIF)和结缔组织生长因子(connective tissue growth factor,CTGF)的表达情况及其对预后的影响。方法应用免疫组织化学染色法检测MIF和CTGF在84例食管癌组织中的表达水平,应用Cox回归模型和Kaplan-Meier生存曲线分析其与患者预后的关系。结果本组病例3年生存率为59.5%(50/84)。MIF和CTGF的表达与肿瘤浸润深度(P=0.006,P=0.011)和肿瘤的临床分期(P=0.023,P=0.006)密切相关。单因素生存分析表明,MIF和CTGF低表达组较高表达组均有生存优势,差异均有统计学意义(P<0.05)。Cox模型多因素分析表明,食管癌组织中CTGF表达水平、临床分期和肿瘤分化程度是影响食管癌患者生存的独立预后因素(P<0.05)。结论食管癌组织中CTGF高表达、肿瘤低分化和临床分期较晚与患者预后不良显著相关。
Objective To investigate the expression of macrophage migration inhibitory factor (MIF) and connective tissue growth factor (CTGF) in esophageal carcinoma and its effect on prognosis. Methods Immunohistochemical staining was used to detect the expression of MIF and CTGF in 84 cases of esophageal cancer. The relationship between the expression of MIF and prognosis was analyzed by Cox regression model and Kaplan-Meier survival curve. Results The 3-year survival rate of this group was 59.5% (50/84). The expression of MIF and CTGF was closely related to the tumor invasion depth (P = 0.006, P = 0.011) and the clinical stage (P = 0.023, P = 0.006). Univariate survival analysis showed that MIF and CTGF low expression group had higher survival expression, the differences were statistically significant (P <0.05). Multivariate analysis of Cox model showed that the expression of CTGF in esophageal cancer, clinical stage and degree of tumor differentiation were independent prognostic factors of esophageal cancer survival (P <0.05). Conclusion The high expression of CTGF in esophageal cancer tissue, poorly differentiated tumor and clinical stage were associated with poor prognosis.