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1986年10月至1988年4月 Ludwigshafen 妇女医院对120例单胎妊娠经腹绒毛活检,平均年龄36.4岁。适应证:母龄≥35岁;孕10周1例,孕11～13周70例,孕14～16周21例,孕17～19周19例,孕20～22周9例。胎盘附着宫底8例,侧壁14例,后壁33例,前壁65例。活检后一天超声监护,一周后复查。为诊断开放性神经管缺陷,自孕17周测定血清甲胎蛋白(AFP)及孕21～22周时超声检查。活检时取仰卧位,超声显示胎盘并确定穿刺位置。受检前膀胱必需充盈。腹部消毒、铺巾后,在
From October 1986 to April 1988, Ludwigshafen Women’s Hospital conducted a total of 120 singleton pregnancies with a mean age of 36.4 years. Indications: mother’s age≥35 years; 1 case of pregnancy 10 weeks, 70 cases of 11 to 13 weeks of pregnancy, 21 cases of 14 to 16 weeks of pregnancy, 19 cases of pregnancy 17 to 19 weeks, 9 cases of pregnancy 20 to 22 weeks. Eight cases of placenta attached to the end of the palace, 14 cases of the lateral wall, 33 cases of posterior wall, 65 cases of anterior wall. One day after biopsy ultrasound monitoring, a week after the review. To diagnose open neural tube defects, serum alpha-fetoprotein (AFP) was measured at 17 weeks of pregnancy and sonography at 21-22 weeks of gestation. Biopsy supine position, ultrasound shows the placenta and determine the puncture position. Pre-test bladder must be filled. Abdominal disinfection, shop towels, in