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目的通过测定冠心病患者行冠状动脉介入治疗前后血浆高敏C反应蛋白(hs-CRP)及基质金属蛋白酶-9(MMP-6)的血浆浓度,分析冠状动脉支架术对冠心病患者炎症指标的影响。方法选择经冠状动脉介入治疗单支病变的冠心病患者70例作为介入组,40例经冠状动脉造影证实冠状动脉正常的人作为对照组。分别采用免疫浊度法和酶联免疫吸附法检测入选者冠状动脉介入治疗前后hs-CRP和MMP-1水平。结果介入组患者术后血浆hs-CRP水平显著高于术前的,而对照组冠状动脉造影术后hs-CRP与术前的相比无显著性差异(P>0.05)。介入组患者术后血浆MMP-1显著高于术前,而对照组冠脉造影术后MMP-1与术前的相比无显著性差异(P>0.05)。结论冠脉介入治疗可促进冠心病患者血浆hs-CRP及MMP-1水平的升高,是否为冠脉介入治疗术后支架内再狭窄的重要机制尚待进一步考证。
Objective To investigate the effect of coronary artery stenting on inflammatory markers in patients with coronary heart disease (CHD) by measuring plasma concentrations of hs-CRP and MMP-6 before and after coronary intervention . Methods Seventy patients with coronary artery disease undergoing coronary artery interventional therapy for coronary artery disease were selected as the intervention group. Forty patients with normal coronary artery confirmed by coronary angiography were selected as the control group. The levels of hs-CRP and MMP-1 were measured before and after coronary intervention with immunoturbidimetric assay and enzyme-linked immunosorbent assay respectively. Results The plasma levels of hs-CRP in the intervention group were significantly higher than those in the preoperative group. There was no significant difference in hs-CRP between the control group and the preoperative one (P> 0.05). The plasma level of MMP-1 in the intervention group was significantly higher than that in the preoperative group, while there was no significant difference in the MMP-1 level between the control group and the preoperative group (P> 0.05). Conclusion Coronary intervention may promote the increase of plasma hs-CRP and MMP-1 levels in patients with coronary heart disease, and whether this is an important mechanism of in-stent restenosis after coronary intervention remains to be further studied.