Oncogenic potential of IDH1R132C mutant incholangiocarcinoma development in mice

• 作 者: Ding Ning Che Li Li Xiao-Le
• 机 构: PekingUnivCancHosp&,Inst,UnivCalifSanFrancisco,FourthMilMedUniv,HubeiUnivChineseMed
• 出 处: 世界胃肠病学杂志：英文版
• 发表日期: 2016年6期
• 关键词: IDH1 MUTANT NOTCH PATHWAY Intrahepaticcholangiocarcinoma MOUSE LIVER cancer p53
• 基金项目: Supported by Grants from National Institutes of Health,No.R01CA136606(in part,to Chen X),,UCSF Liver Center,No.P30DK026743,,China Scholarship Council,contract,No.201206010086(to Ding N)and No.20130659

AIM To investigate whether IDH1R132C mutant incombination with loss of p53 and activated Notchsignaling promotes intrahepatic cholangiocarcinoma（ICC） development.METHODS： We applied hydrodynamic injection andsleeping beauty mediated somatic integration to