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以氚-胸腺嘧啶核苷(~3H—TdR)体外参入慢性胃炎和胃癌牯膜,用放射自显影术测定细胞周期参数。 胃粘膜的标记率代表上皮细胞的增殖率,标记率随胃粘膜的病变不同而异,与病变部位无关。伴有肠化生的萎缩性胃炎与胃癌在高增殖率和增殖区向表面扩展这两方面部十分相似。 用体外双标记法测定细胞周期参数T_2和T_c。胃癌细胞群体的S期时间较萎缩性胃炎延长。癌旁组织的S期时间较萎缩性胃炎缩短。其意义有待进一步研究。
The chronic gastritis and gastric cancer decidua were incubated with thymidine-thymidine (~3H-TdR) in vitro and the cell cycle parameters were determined by autoradiography. The labeling rate of gastric mucosa represents the proliferation rate of epithelial cells, and the labeling rate varies with the lesions of gastric mucosa, and has nothing to do with the lesion. Atrophic gastritis with intestinal metaplasia and gastric cancer are very similar in both the high proliferation rate and the surface area of the proliferative zone. Cell cycle parameters T_2 and T_c were measured by in vitro double labeling. The S phase of gastric cancer cell population prolonged compared with atrophic gastritis. The period of S-phase of adjacent tissues is shorter than atrophic gastritis. Its significance is for further study.