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目的建立本实验室检测舟山海岛妇女妊娠期特异的甲状腺激素的参考区间,并分析其在妊娠早期、中期、晚期的变化趋势。方法选择健康妊娠妇女300例,分别在妊娠早期(1周~12周)、妊娠中期(13周~27周)、妊娠晚期(28周~40周)进行甲状腺激素检测。经统计分析得到各组甲状腺激素的参考区间,并分析其不同时期的变化趋势。结果妊娠早期、中期、晚期TT3、TT4、FT4均显著高于未妊娠组,差异有统计学意义(P<0.01);FT3在妊娠早期最高,高于未妊娠组,差异有统计学意义(P<0.01);TT3、TT4、FT3、FT4在妊娠期随孕周逐渐下降。TSH在妊娠早期最低,并随孕周增加而逐渐升高,在妊娠晚期接近未妊娠组水平。结论了解妊娠期甲状腺激素变化规律,建立本地区妊娠期特异的甲状腺激素参考区间有助于临床诊断、治疗与测监妊娠期甲状腺疾病,降低不良妊娠结局的发生。
Objective To establish a reference interval of pregnancy-specific thyroid hormone in Zhoushan Island women in our laboratory and analyze its changing trend in early, middle and late pregnancy. Methods Thirty healthy pregnant women were selected and tested for thyroid hormone in the first trimester of pregnancy (week 1 ~ week 12), second trimester of pregnancy (week 13 ~ week 27) and second trimester of pregnancy (week 28 ~ week 40). By statistical analysis, the reference intervals of thyroid hormones in each group were obtained, and the trend of changes in different periods was analyzed. Results The levels of TT3, TT4 and FT4 in early, middle, late pregnancy were significantly higher than those in non-pregnant women (P <0.01). FT3 was the highest in early pregnancy and higher than that in non-pregnant women, the difference was statistically significant (P <0.01). The levels of TT3, TT4, FT3 and FT4 in pregnancy decreased gradually with gestational age. TSH in the first trimester of pregnancy, and gradually increased with the gestational age increased in the third trimester of pregnancy close to the level of non-pregnant group. Conclusions Understanding thyroid hormone variation during pregnancy and establishing a reference interval of thyroid hormone during gestation in our region are helpful for the clinical diagnosis, treatment and monitoring of thyroid diseases in pregnancy and the incidence of adverse pregnancy outcomes.