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目的 探索批质量保证二次抽样法 (DLQAS)在抗疟药对恶性疟疗效监测中应用的可能性。 方法 在现场按WHO推荐的 2 8d体内法氯喹疗效评估方案收集病例 ,给予氯喹治疗 ,判定治疗失败与否 ,比较传统的流行病学方法与DLQAS法对疗效判定的结果 ,评估和比较对样本量的需求。 结果 传统方法调查到治疗失败率为 40 .7% ,DLQAS法第一阶段和第二阶段调查到治疗失败率均大于WHO推荐换用药物治疗失败率上限 2 5 % ;DLQAS法的样本量比传统的流行病学横断面抽样方法少。 结论 DLQAS的现场调查治疗失败判定结果同传统流行病学方法 ,且样本量小、快速 ,适用于对抗疟药治疗恶性疟疗效监测的现场评估。
Objective To explore the possibility of applying DLQAS in the monitoring of the efficacy of antimalarial drugs against P. falciparum. Methods On the site, the patients were enrolled in the 28-day in-vivo chloroquine curative effect evaluation protocol recommended by the WHO. Chloroquine was administered to determine whether the treatment failed or not. The traditional epidemiological methods and DLQAS were used to evaluate the curative effect. The demand. Results The failure rate of traditional method was 40.7%. The first and second stages of DLQAS were higher than the upper limit of failure rate of drug treatment recommended by WHO. The sample size of DLQAS was lower than that of traditional There are few epidemiological cross-sectional sampling methods. Conclusions DLQAS field test failed to determine the results with the traditional epidemiological methods, and the sample size is small, fast, suitable for anti-malaria treatment of falciparum efficacy monitoring field assessment.