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目的了解石家庄市健康人群百日咳抗体水平,为百日咳防控提供参考。方法 2013年采用多阶段分层随机抽样的方法,对石家庄市1 634名人群开展问卷调查和采集血标本,用酶联免疫吸附试验检测百日咳IgG抗体。结果人群百日咳抗体阳性率50.18%、平均浓度52.88 IU/ml。各年龄组之间百日咳抗体阳性率差异有统计学意义(χ~2=79.756,P<0.01)。<1岁组为45.04%,随年龄增长抗体阳性率下降并维持在较低水平,15岁之后有所反弹,至40~组达到最高68.57%;百日咳抗体阳性率平原县高于山区县,地区之间差异有统计学意义(χ~2=16.03 P<0.01);不同性别间抗体阳性率和平均浓度的差异均无统计学意义(χ~2=1.120,P=0.290;t=0.053,P=0.819);百日咳抗体阳性率、平均浓度在末次接种后1~5年内达到最低;基础免疫与加强免疫组间抗体阳性率和平均浓度差异无统计学意义(χ~2=2.738,P=0.098;t=0.302,P=0.583)。结论百白破混合制剂中,百日咳菌苗免疫效果欠佳。应加强监测,控制传染源。
Objective To understand the level of pertussis antibodies in healthy people in Shijiazhuang and to provide a reference for prevention and control of whooping cough. Methods A multistage stratified random sampling method was used in 2013 to conduct a questionnaire survey and collect blood samples from 1 634 people in Shijiazhuang City, and the pertussis IgG antibody was detected by enzyme-linked immunosorbent assay. Results The prevalence of pertussis antibody in the crowd was 50.18% with an average concentration of 52.88 IU / ml. The positive rate of pertussis antibody among all age groups had significant difference (χ ~ 2 = 79.756, P <0.01). <1 year old group was 45.04%. With the increase of age, the positive rate of antibody decreased and remained at a low level, after 15 years old, it rebounded to the highest level of 68.57% in 40 ~ group. The positive rate of pertussis antibody in plain county was higher than that in mountainous counties and regions (Χ ~ 2 = 16.03 P <0.01). There was no significant difference in antibody positive rate and average concentration between different sex (χ ~ 2 = 1.120, P = 0.290; t = 0.053, P = 0.819). The average positive rate of pertussis antibody reached the lowest within 1 to 5 years after the last vaccination. There was no significant difference in antibody positive rate and average concentration between the two groups (χ ~ 2 = 2.738, P = 0.098) ; t = 0.302, P = 0.583). Conclusion Pertussis mixed vaccine formulations, pertussis vaccine immunization ineffective. We should step up monitoring and control of sources of infection.