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目的:分析探讨急性白血病患者并发感染时经验性应用抗菌药物现状。方法:采用整体分析方法,调查我院血液科102例急性白血病并发感染的患者抗菌药物的使用情况,并对抗菌药物的种类、用药频度以及病原学检测对抗菌药物的指导意义进行分析。结果:102例患者中,除了3例死于重症感染外,总体有效率91.2%。病原学检测88例,培养出致病菌株25株(28.4%),所用抗菌药物已覆盖敏感菌谱的有14例,覆盖率56%。结论:急性白血病患者并发感染时,应及时给予经验性抗菌药物的应用及进行细菌学检查。
Objective: To analyze the status of empirical application of antimicrobial agents in patients with acute leukemia complicated by infection. Methods: The overall analysis was used to investigate the use of antimicrobial agents in 102 patients with acute leukemia complicated with infection in our department of hematology. The types of antimicrobial agents, frequency of drug use and the guidance of antimicrobial agents by pathogenic tests were analyzed. Results: Of the 102 patients, except for 3 patients who died of severe infection, the overall effective rate was 91.2%. Etiological detection of 88 cases, 25 strains of pathogens were cultured (28.4%), antimicrobial drugs used in 14 cases have covered sensitive spectrum, the coverage rate of 56%. Conclusion: In patients with acute leukemia complicated by infection, the timely application of empirical antibiotics and bacteriological examination.