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目的探讨流行性脑脊髓膜炎球菌所致中枢神经系统感染后 ,脑脊液中NO含量变化及其与脑损害程度间的相关关系。方法测量伴有不同脑损害程度的流行性脑脊髓膜炎患儿脑脊液中NO-2 含量 ,分析脑脊液中NO- 2 含量变化与脑损害程度的关系。结果流行性脑脊髓膜炎患儿脑脊液中NO- 2 含量明显上升 ,其上升幅度与脑损害程度相关。脑损害程度重的患儿其脑脊液中NO-2 含量高于脑损害程度轻的患儿。结论流行性脑脊髓膜炎患儿脑脊液中NO-2 含量升高 ,其升高幅度与脑损害程度相关 ,推测测量脑脊液中NO- 2 含量可能会有助于判断流行性脑脊髓膜炎患儿脑损害程度。
Objective To investigate the change of NO content in cerebrospinal fluid (CSF) and its relationship with the degree of brain damage after central nervous system infection caused by epidemic cerebrospinal meningococci. Methods The levels of NO-2 in cerebrospinal fluid of children with epidemic cerebrospinal meningitis with different degrees of brain damage were measured. The relationship between NO-2 content in cerebrospinal fluid and the degree of brain damage was analyzed. Results The content of NO-2 in cerebrospinal fluid of children with epidemic cerebrospinal meningitis increased significantly, and the increase rate correlated with the degree of brain damage. Children with severe brain damage have higher levels of NO-2 in cerebrospinal fluid than those with mild brain damage. Conclusions The content of NO-2 in cerebrospinal fluid of children with epidemic cerebrospinal meningitis is increased, which is related to the degree of brain damage. Speculating the measurement of NO-2 in cerebrospinal fluid may be helpful in judging the prognosis of children with epidemic cerebrospinal meningitis Brain damage.