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目的观察尿白三烯(LTs)E4(LTE4)在儿童典型川崎病(KD)中的变化,探讨是否可以将LTs作为KD后的监测指标。方法东南大学附属盐城医院儿科2007年10月至2010年9月收治68例完全性KD患儿,采用竞争性酶联免疫吸附技术检测其在治疗前后尿LTE4水平,55名正常儿童尿LTE4作为对照组,同时对KD急性期患儿行心脏彩超检查,分为有冠状动脉损害组(8例)和无冠状动脉损害组(60例)。结果 KD患儿治疗前尿LTE4均高于正常对照组,差异有统计学意义(P<0.01);恢复期与正常对照组比较,差异无统计学意义(P>0.05);KD合并冠状动脉损害组尿LTE4明显高于无冠状动脉损害组,差异有统计学意义(P<0.01);所有KD患儿治疗前后比较,LTE4均明显降低(P<0.01)。结论 KD尤其是合并冠状动脉损害的患儿LTs水平明显增高,尿LTE4可作为KD后临床监测指标,可以考虑通过早期应用LTs受体拮抗剂干预来达到预防合并冠状动脉病变发生、促进冠状动脉损伤修复的目的。
Objective To investigate the changes of urinary leukotrienes (LTs) E4 (LTE4) in children with Kawasaki disease (KD) and to explore whether LTs can be used as a monitoring indicator after KD. Methods A total of 68 children with complete KD were admitted to Yancheng Hospital of Southeast University from October 2007 to September 2010. Urinary LTE4 levels were measured before and after treatment by competitive enzyme-linked immunosorbent assay (ELISA). 55 normal children with urinary LTE4 as control At the same time, children with acute KD underwent echocardiography. The patients were divided into coronary artery injury group (n = 8) and coronary artery injury group (n = 60). Results Before treatment, urinary LTE4 in children with KD was significantly higher than that in the normal control group (P <0.01). There was no significant difference between the two groups (P> 0.05). KD complicated with coronary artery lesion LTE4 in group K was significantly higher than that in group without coronary artery injury (P <0.01). The levels of LTE4 in all children with KD were significantly lower than those before treatment (P <0.01). Conclusion KD, especially in children with coronary artery lesions significantly increased LTs, urinary LTE4 can be used as a clinical monitoring of KD indicators can be considered through the early application of LTs receptor antagonist intervention to prevent the occurrence of coronary artery lesions and promote coronary artery injury The purpose of repair.