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目的：探讨补充硒以减轻５－氟尿嘧啶（５－ＦＵ）对大鼠脂质过氧化损害的机制。方法：６０只大鼠随机分为补硒组（Ｓｅ）和非补硒组（ＮＳｅ），经腹腔注射５－ＦＵ后，分别于注射前及注射后第１、３、５天处死，检测大鼠血液、心、肝、肾及空肠粘膜内丙二醛含量及谷胱甘肽过氧化物酶活性。结果：在Ｓｅ组，血中及空肠粘膜内丙二醛含量在注射５－ＦＵ后第１、３天，心、肝、肾组织内丙二醛含量在注射５－ＦＵ后第３天显著低于ＮＳｅ组；红细胞谷胱甘肽过氧化物酶活性在注射５－ＦＵ后一直显著高于ＮＳｅ组（Ｐ＜０．０１），空肠粘膜在注射５－ＦＵ后第１天，心、肝、肾组织内在注射５－ＦＵ后第３天，谷胱甘肽过氧化物酶活性显著高于ＮＳｅ组（Ｐ＜０．０５）。结论：补充硒有助于减轻５－ＦＵ对大鼠的脂质过氧化损害。
Objective: To investigate the mechanism of selenium supplementation to reduce the damage of lipid peroxidation induced by 5-fluorouracil (5-FU) in rats. Methods: Sixty rats were randomly divided into selenium group (Se) and non-selenium group (NSe). After intraperitoneal injection of 5-FU, rats were sacrificed on the 1st, 3rd and 5th day after injection, Malondialdehyde content and glutathione peroxidase activity in blood, heart, liver, kidney and jejunum mucosa of rats. Results: In the Se group, the content of malondialdehyde in the blood and jejunal mucosa was significantly lower on the 3rd day after injection of 5-FU In the NSe group, glutathione peroxidase activity of erythrocytes was significantly higher than NSe group (P <0.01) after injection of 5-FU. On the first day after 5-FU injection, On the 3rd day after injection of 5-FU, the activity of glutathione peroxidase in renal tissue was significantly higher than that in NSe group (P <0.05). CONCLUSIONS: Selenium supplementation helps to reduce lipid peroxidation damage induced by 5-FU in rats.