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目的:探讨羊膜腔内推注地塞米松对妊娠期糖尿病(GDM)孕妇及围生儿的影响。方法:采用B超引导下羊膜腔内推注地塞米松的方法,对30例GDM孕妇(观察组)给予促胎肺成熟治疗,以了解羊膜腔内推注治疗的安全性及对GDM孕妇及围生儿的影响。50例GDM孕妇(对照组)不以任何途径应用地塞米松促胎肺成熟。结果:30例观察组孕妇,推注治疗30次,均为1次穿刺完成推注,推注成功率100%。应用地塞米松后母体代谢无明显变化(P>0.05);观察组与对照组新生儿呼吸窘迫综合征(NRDS)发生率比较差异有统计学意义(P<0.05)。结论:经腹羊膜腔内推注地塞米松促胎肺成熟是一种简便、可行、安全、有效的方法,是GDM孕妇促胎肺成熟的最佳选择,对母体及围生儿无不良影响,可直接有效地促进胎儿肺成熟,减少NRDS的发生,具有较高的临床应用价值。
Objective: To investigate the effect of amniocentesis on dexamethasone in gestational diabetes mellitus (GDM) pregnant women and perinatal children. Methods: 30 cases of GDM pregnant women (observation group) were given fetal lung maturation therapy by B-ultrasound guided intra-amniotic injection of dexamethasone to understand the safety of amniotic cavity bolus injection and to evaluate the safety of GDM in pregnant women and Perinatal effects. 50 pregnant women with GDM (control group) did not use dexamethasone in any way to promote fetal lung maturation. Results: 30 pregnant women in the observation group were treated with bolus injection 30 times. All of them were injected by one puncture, and the success rate of injection was 100%. There was no significant change in maternal metabolism after dexamethasone administration (P> 0.05). The incidence of neonatal respiratory distress syndrome (NRDS) in observation group and control group was significantly different (P <0.05). Conclusion: Intraperitoneal injection of dexamethasone to promote fetal lung maturity is a simple, feasible, safe and effective method for GDM pregnant women to promote fetal lung maturity of the best choice, no adverse effects on the maternal and perinatal children , Can directly and effectively promote fetal lung maturation, reduce the occurrence of NRDS, with high clinical value.