论文部分内容阅读
用乳化技术制备了三种微球体系,分别命名为Ⅰ、Ⅱ、Ⅲ。Ⅰ是乳剂通过戊二醛交联的方法制成,Ⅱ是在戊二醛交联的基础上用甘氨酸处理的产品,Ⅲ是乳剂通过加热固化法而制得的微球。结果发现,相同的乳剂经交联法制得的微球其直径比加热固化法制得的微球大。微球Ⅱ和微球Ⅰ有更好的亲水性。微球Ⅰ和Ⅱ中 MTX 的含量分别为2.73±0.05%和2.87±0.12%。Ⅲ是空白微球表面吸附了 MTX 结晶的一种体系。微球中 MTX 的体外释放实验证实,Ⅰ和Ⅱ在 pH 7.4的磷酸盐缓冲液中,药物释放达24小时之久其机理属 Higuchi 扩散。
Three kinds of microspheres system were prepared by emulsification technology, named as Ⅰ, Ⅱ and Ⅲ respectively. Ⅰ is prepared by cross-linking the emulsion through glutaraldehyde, Ⅱ is the product treated with glycine on the basis of cross-linking of glutaraldehyde, and Ⅲ is the microballoon prepared by heating and curing the emulsion. The results showed that the diameter of the microspheres prepared by the same emulsion crosslinking method is larger than the microspheres prepared by the heat curing method. Microspheres Ⅱ and microspheres Ⅰ have better hydrophilicity. The contents of MTX in microspheres Ⅰ and Ⅱ were 2.73 ± 0.05% and 2.87 ± 0.12%, respectively. Ⅲ is a system in which MTX crystals are adsorbed on the surface of blank microspheres. Microspheres MTX in vitro release experiments confirmed that Ⅰ and Ⅱ in pH 7.4 phosphate buffer, the drug release for 24 hours its mechanism is Higuchi diffusion.