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Objective: To overall evaluate the change of global cardiac systolic performance and diastolic filling in hypovoleamia byLBNP. Methods: 10 healthy male subjects were placed in a standard LBNP chamber. Baseline haemodynamic and echocar-diographic measurements were made after a period of least 10 min resting supine within the chamber. Pressure was then de-creased to - 10, - 20 and - 30 mmHg, with each pressure maintained for 15 min. The indices of four transvalvular and SVCflow were measured using Doppler echocardiography. Results: The results showed that S wave, Re wave, and VTI of SVCprogressively decreased with increasing LBNP. At - 30 mmHg stage, S wave decreased by 35.4 %( change of 0.21+0.03 m /s,P < 0.001). This reduction in pre-load was associated with a progressive decrease in SV(by 21.5 ±4.5 ml at -30 mmHg, P < 0.001) ,decrease in CO( by 1.2 ±0.2 L min-1 at - 30 mmHg LBNP, P < 0.001) . The diastolic filling of mitral and tricuspid flow alsoreduced significantly. At - 30 mmHg stage, the E wave of MVF and TVF decreased 31% and 32% respectively ( change of0.23 ±0.05 m/s, P < 0.001 and 0.18 ±0.01 m /s, P < 0.001) . VTI of MVF and TVF decreased 27% and 27.7% respective-ly( change of 5.55 ±1.41cm, P < 0.01 and 4.25 ±0.44 cm, P < 0.01) . A wave of both sides did not change significantly.Conclusion: Doppler indices changes in different LBNP stage can roughly reflect the degree of hypovoleamia caused by bloodvolume redistribution. The indices of Doppler echocardiography are more sensitive than traditional physiological indexes inevaluating cardiovascular responses of LBNP. Echocardiography techniques overall can evaluate the global cardiac function in-cluding systolic performance and diastolic filling.
Objective: To overall evaluate the change of global cardiac systolic performance and diastolic filling in hypovoleamia by LBNP. Methods: 10 healthy male subjects were placed in a standard LBNP chamber. Baseline haemodynamic and echocar-diographic measurements were made after a period of least 10 min. Supine within the chamber. Pressure was then de-creased to - 10, -20 and - 30 mmHg with each pressure maintained for 15 min. The indices of four transvalvular and SVC flow were measured using Doppler echocardiography. Results: The results showed that S wave, Re wave, and VTI of SVC progressively decreased with increasing LBNP. At - 30 mmHg stage, S wave decreased by 35.4% (change of 0.21 + 0.03 m / s, P <0.001) a progressive decrease in SV (by 21.5 ± 4.5 ml at -30 mmHg, P <0.001), decrease in CO (by 1.2 ± 0.2 L min-1 at -30 mmHg LBNP, P <0.001) tricuspid flow alsoreduced significantly. At - 30 mmHg stage, the E wave of MVF and TVF decreased 31% and 32% respectively (change of 0.23 ± 0.05 m / s, P <0.001 and 0.18 ± 0.01 m / s, P <0.001) % and 27.7% respectively-ly (change of 5.55 ± 1.41 cm, P <0.01 and 4.25 ± 0.44 cm, P <0.01). A wave of both sides did not change significantly. Conclusions: Doppler indices changes in different LBNP stages can be roughly reflect the degree of hypovoleamia caused by blood volume redistribution. The indices of Doppler echocardiography are more sensitive than the traditional physiological indexes inevaluating cardiovascular responses of LBNP. Echocardiography techniques overall can evaluate the global cardiac function in-cluding systolic performance and diastolic filling.