Influence ofWithania somnifera on obsessive compulsive disorder in mice

• 作 者: Bhanu PS Kaurav Manish M Wanjari Amol Chandekar Nagendra Singh Chauhan Neeraj Upmanyu
• 机 构: Department of Pharmacology, R.K.D.F. College of Pharmacy, Bhopal M.P. India“,”Department of Pharmaco
• 出 处: 亚太热带医药杂志（英文版）
• 发表日期: 2012年5期
• 关键词: Withania somnifera Fluoxetine Ritanserin Parachlorophenylalanine Obsessive compu

ABSTRACT Objective:To study the influence of methanolic and aqueous extract ofWithania somnifera (W. somnifera) root on the marble-burying behavior of mice a well-accepted model of obsessive compulsive behavior.Methods:Mice were divided in different groups(n=6).Fluoxetine(5,10,15 mg/kg), (10,25,50,100 mg/kg) and methanolic extractW. somnifera(MEWS)(10,25,50,100 mg/kg) were administered i.p.30 min. prior to the assessment of marble burying behavior and locomotor activity.The control group received vehicle of the extract.Results:Administration of aqueous extractsW. somnifera(AEWS) andMEWS(50 mg/kg) successively decreaesed the marble burying behavior activity without affecting motor activity.This effect ofAEWS andMEWS was comparable to standard fluoxetine, ritanserin and parachlorophenylalanine.Conclusions:W. somnifera extract is effective in treating obsessive compulsive disorder.