论文部分内容阅读
目的观察对葡萄糖耐量试验异常的中高危高血压患者进行干预12个月后血压及糖代谢的情况。方法对213例葡萄糖耐量减低(IGT)的高血压患者随机分为生活方式控制组(LC)、生活方式控制加二甲双胍组(LC+M)、生活方式控制加阿卡波糖组(LC+A)三组,分析干预12个月后各组IGT转化为正常葡萄糖耐量(NGT)和新发糖尿病(DM)的发生率以及血压与IGT、NGT、DM之间的关系。结果三组干预12个月后,2hPG均明显降低(P<0.01),与LC组比,LC+M组和LC+A组转为NGT的人数均明显增多(P<0.01),LC+M组和LC+A组相比,在转为NGT和DM的人数方面差异无统计学意义(P>0.05),且血压越达标,糖尿病发生率越低。结论对糖耐量异常的高血压患者,积极的进行干预,可以减少糖尿病的发生,生活方式控制加药物治疗优于单纯生活方式控制。
Objective To observe the changes of blood pressure and glucose metabolism in middle-high-risk hypertensive patients with impaired glucose tolerance test after 12 months intervention. Methods 213 hypertensive patients with impaired glucose tolerance (IGT) were randomly divided into the lifestyle control group (LC), the lifestyle control plus metformin group (LC + M), the lifestyle control plus acarbose group (LC + A ), And analyzed the incidence of IGT conversion to normal glucose tolerance (NGT) and neoadjuvant diabetes (DM) and the relationship between blood pressure and IGT, NGT and DM after 12 months of intervention. Results Compared with LC group, the number of NGT patients in LC + M group and LC + A group increased significantly (P <0.01), LC + M Compared with LC + A group, there was no significant difference in the number of patients who switched to NGT and DM (P> 0.05), and the more the blood pressure reached the standard, the lower the incidence of diabetes. Conclusion For patients with impaired glucose tolerance, active intervention can reduce the incidence of diabetes. Life style control and medication are better than those of simple lifestyle control.