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目的 探讨早产儿脑室周围白质软化 (PVL)的高危因素。方法 对合并PVL与未合并PVL的早产儿(各 2 6例 )进行病例对照研究 ,对 18种危险因素进行Logistic回归分析。结果 胎膜早破 (PROM )、生后 4h内的pH值、动脉氧分压、生后 3d内最低二氧化碳分压、生后第 1周超声发现脑室周围强回声团 (PVE)的OR值分别为 2 383、3 2 77、3 76 9、3 96 5、1 931(P <0 0 1)。建立的早产儿PVL主效应模型为Logit(P) =β0 +0 897PROM - 1 346PaO2 - 1 2 78pH - 1 4 6 7PaCO2 +0 792PVE(χ2 =2 1 378,P =0 0 0 1)。结论 PROM、低氧血症、酸中毒、低碳酸血症、PVE为早产儿PVL的高危因素。
Objective To investigate the risk factors of periventricular leukomalacia (PVL) in preterm infants. Methods A case-control study was conducted in preterm infants with and without PVL (26 cases each), and 18 risk factors were analyzed by Logistic regression. Results PROM, pH value within 4 hours after birth, partial pressure of arterial oxygen, lowest partial pressure of carbon dioxide within 3 days after birth, OR value of periventricular echogenic mass (PVE) 2 383,3 2 77,3 76 9,3 96 5,1 931 (P <0 0 1). The main model of PVL in preterm infants was Logit (P) = β0 +0 897PROM - 1 346PaO2 - 1 2 78pH - 1 467PaCO2 +0 792PVE (χ2 = 2 1 378, P = 0 0 0 1). Conclusions PROM, hypoxemia, acidosis, hypocapnia and PVE are risk factors for PVL in preterm infants.