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本文报道无先兆偏头痛患者发作期和间歇期颅内大血管对高碳酸血症反应性研究结果。用双侧经颅多普勒(TCD)同时记录以评估左右侧血流速度可能出现的不对称变化。 研究16名患者(6男10女,17～36岁,平均25.8岁)。发作时均为单侧头痛,临床和实验室检查排除内分泌、神经精神和全身性疾病。检查前72小时停用防治偏头痛药和止痛剂。右侧头痛7例,左侧9例。头痛程度均为中等。对照组为16名年龄、性别匹配的健康者。TCD由两个2MHz双功能探头于颞窗采集大脑前、中、后动脉信号。计算屏气指数(breath-holding index,BHI)评价每对血管反应性。BHI由受检查正常呼吸后屏气时间(秒)除屏气时平均血流速度(MFV)升高百分率所得。受检者取仰卧位,连续记录1分钟正常呼吸,获得平静时MFV,屏气后4秒记录MFV,屏气时间固定为30秒,两对血管检查至少间隔10分钟。统计学用方差分析。结果:对照组,患者发作期、间歇期平静时MFV头痛侧与非头痛侧无统计学差异,对照组与患者间歇期(头痛侧和
This article reports the results of a study of hypercapnic reactivity in the intracranial major vessels during the onset and intermission in patients without aura migraine. Bilateral transcranial Doppler (TCD) was recorded simultaneously to assess the possible asymmetric changes in left and right blood flow velocities. Sixteen patients (6 males and 10 females, 17 to 36 years, mean 25.8 years) were studied. Attacks were unilateral headache, clinical and laboratory tests exclude endocrine, neuropsychiatric and systemic diseases. 72 hours before the test to stop the prevention and treatment of migraine drugs and painkillers. Right headache in 7 cases, left in 9 cases. Headache is medium. The control group consisted of 16 healthy and age-matched healthy subjects. TCD by two 2MHz dual-function probe in the temporal window acquisition of the brain before and after the artery signal. Vascular reactivity was evaluated for each pair by calculating breath-holding index (BHI). The BHI is derived from the percentage increase in mean flow velocity (MFV) at breath holding time (in seconds) after breath-hold is checked. Subjects were supine, continuous recording of normal breathing for 1 minute to obtain the calm MFV, recorded 4 seconds after holding breath MFV, breath holding time fixed at 30 seconds, two pairs of vascular examination at least 10 minutes apart. Statistical analysis of variance. Results: In the control group, there was no significant difference between the MFV headache side and the non-headache side in the seizure phase and intermittent sedation. In the control group,