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目的了解子宫内膜癌与单纯疱疹病毒Ⅱ型(HSVⅡ)感染的关系。方法采用聚合酶链反应-单链构象多态性分析(PCR-SSCP)技术检测30例子宫内膜癌,子宫内膜增殖症、正常子宫内膜各15例HSVⅡ感染情况,电子显微镜观察子宫内膜癌癌细胞5例。结果子宫内膜癌HSVⅡ感染阳性率50%(15/30),电子显微镜观察子宫内膜癌癌细胞胞质内可见少量单膜包裹的圆形小体病毒颗粒;子宫内膜增殖症HSVⅡ阳性率6.67%(1/15);15例正常子宫内膜无HSVⅡ感染。子宫内膜癌与子宫内膜增殖症及正常子宫内膜比较,P<0.001,OR=29,RR=2.749,差异极为显著。结论子宫内膜HSVⅡ感染与子宫内膜癌的发生、发展相关,与患者临床分期、病理分化程度有一定的相关性,可能为子宫内膜癌的高危因素之一。
Objective To understand the relationship between endometrial carcinoma and herpes simplex virus type 2 (HSV Ⅱ) infection. Methods PCR-SSCP was used to detect the HSV Ⅱ infection in 30 cases of endometrial carcinoma, endometrial hyperplasia and normal endometrium. The intrauterine infection was observed by electron microscopy Membrane cancer cells in 5 cases. Results The positive rate of HSV Ⅱ infection in endometrial carcinoma was 50% (15/30). The positive rate of HSV Ⅱ in endometrial hyperplasia was observed in the cytoplasm of the endometrial cancer cells by electron microscopy. 6.67% (1/15); 15 cases of normal endometrium without HSV Ⅱ infection. Endometrial cancer and endometrial hyperplasia and normal endometrium, P <0.001, OR = 29, RR = 2.749, the difference is extremely significant. Conclusions Endometrial HSV Ⅱ infection is associated with the occurrence and development of endometrial carcinoma, and has some correlation with clinical stage and pathological differentiation, which may be one of the risk factors of endometrial cancer.