【摘 要】
：
Omega-3 polyunsaturated fatty acids(n-3 PUFAs),essential fatty acids for humans and animals,have been reported to play a beneficial role in a variety of inflammatory diseases.In this study,we investigated the inhibitory effects and potential molecular mec
【机 构】
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College of Veterinary Medicine,Northwest A&F University,Yangling 712100,China;School of Medicine,Nor
论文部分内容阅读
Omega-3 polyunsaturated fatty acids(n-3 PUFAs),essential fatty acids for humans and animals,have been reported to play a beneficial role in a variety of inflammatory diseases.In this study,we investigated the inhibitory effects and potential molecular mechanisms of n-3 PUFAs on the inflammatory response in lipopolysaccharide(LPS)-stimulated mammary alveolar cell line(MAC-T).Results showed that n-3 PUFAs could abate LPS-induced secretions of tumor necrosis factor-α,interleukin(IL)-6 and IL-1β in MAC-T cells through the nuclear transcription factor kappa B(NF-κB)signal pathway.Meanwhile,n-3 PUFA intervention attenuated histopathologic changes of mam-mary glands,the white blood cell number decrease,and the alkaline phosphatase level decrease in the serum of mice challenged by LPS.Furthermore,n-3 PUFA intervention improved the ecolog-ical structure of the flora in terms of the structural disorder of the non-significant dominant flora induced by LPS in mice.Collectively,both in vitro and in vivo experiments revealed that n-3 PUFAs have a positive effect on LPS-induced inflammatory response,which was possibly mediated by the NF-κB signaling pathway and the intestinal microbiota.
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