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目的:探究氨氯地平联合缬沙坦治疗三级原发性高血压的临床疗效。方法:选取2014年12月至2016年12月来广东药科大学附属第一医院治疗的三级原发性高血压患者160例,随机等分为两组。对照组给予氨氯地平,观察组应用氨氯地平联合缬沙坦进行干预。统计两组患者用药后出现心律失常、头痛水肿、腹痛腹泻、食欲不振等不良反应率,以及血压、心率变化情况。结果:观察组患者在服药后出现心律失常、头痛水肿、腹痛腹泻、食欲不振等不良反应率均少于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组患者血压、心率变化均优于对照组,差异具有统计学意义(P<0.05)。结论:临床针对三级原发性高血压患者给予氨氯地平和缬沙坦治疗效果好,可以降低用药后出现头痛水肿、腹痛腹泻等不良反应,改善患者血压和心率。
Objective: To investigate the clinical efficacy of amlodipine combined with valsartan in the treatment of three-stage essential hypertension. Methods: From December 2014 to December 2016, 160 patients with grade 3 essential hypertension treated at the First Affiliated Hospital of Guangdong Pharmaceutical University were randomly divided into two groups. The control group was given amlodipine, and the observation group was treated with amlodipine and valsartan. The incidence of adverse reactions, such as arrhythmia, headache and edema, abdominal pain and diarrhea, loss of appetite and blood pressure and heart rate were measured after treatment. Results: The rate of adverse reactions such as arrhythmia, headache and edema, abdominal pain and diarrhea and loss of appetite were lower in observation group than those in control group (P <0.05). After treatment, the changes of blood pressure and heart rate in the observation group were better than those in the control group, the difference was statistically significant (P <0.05). Conclusions: The clinical efficacy of amlodipine and valsartan in patients with grade-3 essential hypertension is good, which can reduce headache and edema, abdominal pain and diarrhea and other adverse reactions and improve blood pressure and heart rate.